Aspects of the Testicular Toxicity of Phthalate Esters
نویسندگان
چکیده
منابع مشابه
Aspects of the testicular toxicity of phthalate esters.
Di(2-ethylhexyl) phthalate (DEHP) produced seminiferous tubular atrophy and reductions in seminal vesicle and prostate weight in 4-week-old, but not in 15-week-old rats. Di-n-pentyl phthalate (DPP) did produce atrophy in the older rats but this developed more slowly than in young animals. Coadministration of testosterone or gonadotrophins did not protect against phthalate-induced testicular tox...
متن کاملTesticular effects of phthalate esters.
The testicular effects produced by di(2-ethylhexyl) phthalate (DEHP) in the rat, characterized by a decrease in the relative organ weight and histological changes in the seminiferous tubules, can also be produced by di-n-butyl, di-n-pentyl and di-n-hexyl phthalates. The corresponding monoesters of these compounds, formed in vivo as a result of the action of nonspecific esterases in the intestin...
متن کاملMitochondrial toxicity of phthalate esters.
The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-...
متن کاملTeratogenicity, mutagenicity, and cellular toxicity of phthalate esters.
Growing concern that phthalic acid esters (PAE) may present a health hazard and possible deleterious effects on the ecological system has led to increased interest in the more subtle toxicity of those compounds. Although the acute toxicity of PAEs as a group is quite low, the intrinsic cellular toxicity increases with molecular weight. Whether the intrinsic toxicity is great enough to exert a s...
متن کاملAssessment of the mutagenicity of phthalate esters.
The Ames assay was used to investigate the mutagenicity of several phthalate esters as an approximation of their carcinogenic potential. The ortho diesters, dimethyl phthalate (DMP) and diethyl phthalate (DEP) produced a positive dose-related mutagenic response with Salmonella TA100, but only in the absence of S-9 liver enzymes. Dibutyl, di(2-ethylhexyl), mono(2-ethylhexyl), and butyl benzyl ph...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1986
ISSN: 0091-6765
DOI: 10.2307/3430187